|
Celiac Disease and Grindstone Breads
Celiac Disease (CD) is an inflammatory illness that leads to destruction of the microscopic fingerlike projections of the small intestine called villi. The disease is triggered by ingestion of the gluten proteins contained in Wheat, Spelt, Barley, and Rye, and symptoms range from minor complaints to severe nutrient malabsorption
Wheat, Spelt, Rye, and Barley are related cereals of the family Triticeae and are toxic to patients with CD. Oats can be classified as a cousin of Triticeae and thus a more distant family member. Their storage proteins are collectively called gluten proteins by celiac patients and their physicians, although, strictly speaking, gluten is derived only from the endosperm of wheat grain.
The injurious constituent of wheat for patients with celiac disease is located in a part of gluten called gliadin. As mentioned before, recent studies at Stanford University have identified a sequence of 33 amino acids in gliadin as being responsible for the exceptional toxic potency against the small intestinal mucosa that characterizes CD.
This same sequence was found in other grain proteins like hordeins (from barley), and secalins (from rye), all of which are toxic cereals in the Celiac diet. Proteins in nontoxic food grains, such as avenins (in oats), rice, and maize, do not contain a homologous sequences to the 33 amino acids sequence found in gliadin.
continued in next column
|